Targeted Mechanisms for Proliferation Inhibition and Selective Apoptosis Induction in Cancer Therapy

Abstract:Traditional cancer therapies often suffer from systemic toxicity and lack of selectivity toward malignant cells. Developing targeted therapeutic approaches that selectively eliminate cancer cells while preserving healthy tissues remains a critical challenge in oncology. This study proposes a novel conceptual strategy focusing on the targeted disruption of key cellular proliferation pathways and the selective induction of apoptosis in cancer cells. The mechanism leverages specific biochemical pathways designed to minimize off-target cytotoxicity. Preliminary theoretical models and in vitro frameworks demonstrate enhanced selectivity against malignant cell populations with significantly reduced collateral damage to non-cancerous cells. This approach provides a promising framework for non-toxic targeted oncological therapy and serves as a viable foundation for subsequent preclinical and clinical evaluations.