Key result
Coronary slow flow is linked to ~87% higher serum vaspin levels versus normal flow.
Why the study?
The pathogenesis of coronary slow flow remains unclear despite proposed mechanisms such as endothelial dysfunction, inflammation, and occult atherosclerosis, motivating an investigation into its association with serum adiponectin and vaspin levels.
Are serum vaspin and adiponectin concentrations associated with coronary slow flow in patients undergoing elective coronary angiography without obstructive coronary artery disease?
Cross-Sectional (n=78)
All coronary angiograms were reviewed offline by a single experienced interventional cardiologist who was blinded to the patients' clinical and laboratory data
No
Are serum vaspin and adiponectin concentrations associated with coronary slow flow in patients undergoing elective coronary angiography without obstructive coronary artery disease?
This prospective cross-sectional study provides the first evidence that serum vaspin levels are significantly elevated in patients with coronary slow flow compared to those with normal coronary flow, whereas adiponectin levels do not differ significantly.
Higher vaspin should not yet change practice in coronary slow flow; hypothesis-generating for biomarker role in prospective cohorts.
Aim: Coronary slow flow (CSF) is an angiographic finding characterized by delayed distal vessel opacification in the absence of significant coronary artery disease. Although endothelial dysfunction, inflammation, and occult atherosclerosis have been proposed as possible mechanisms, its pathogenesis remains unclear. This study aimed to investigate the association between serum adiponectin and vaspin levels and coronary slow flow.Materials and Methods: The study included 40 patients with CSF and 38 patients with normal coronary flow who underwent elective coronary angiography. Coronary blood flow was assessed using the Thrombolysis in Myocardial Infarction frame count method, and serum adiponectin and vaspin levels were measured in all participants.Results: Adiponectin levels did not differ significantly between the CSF and normal coronary flow groups. Vaspin levels were significantly higher in the CSF group than in the normal coronary flow group (p < 0.001).Conclusion: Serum vaspin levels were significantly elevated in patients with CSF, suggesting a possible association between increased circulating vaspin concentrations and coronary slow flow.
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Aktüre et al. (2026) conducted a cross-sectional in Coronary slow flow (CSF) (n=78). Serum vaspin and adiponectin levels vs. Normal coronary flow (NCF, n=38) was evaluated on Serum vaspin concentration (ng/mL) in coronary slow flow vs. normal coronary flow (OR 0.000, 95% CI 0.000-0.001, p=<0.001). Serum vaspin levels were significantly higher in patients with coronary slow flow compared to those with normal coronary flow (median 0.168 vs. 0.09 ng/mL, p < 0.001).
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