Androgen-dependent dermatoses in obese adolescent girls: etiopathogenesis and current therapeutic approaches

The adolescence is accompanied by androgenic changes. If this condition is accompanied with obesity, the pathogenetic mechanisms of hyperandrogenism are aggravated, which has even a greater effect on all aspects of the adolescent’s quality of life. The main pathogenic factors of hyperandrogenism in obese adolescent girls include polycystic ovary syndrome, insulin resistance and hyperinsulinemia, lipid imbalance, IGF-1 levels, the hormone-producing capacity of adipose tissue, vitamin D levels, and sleep patterns. Regardless of the cause of androgen-dependent dermatosis, the presence of an obvious cosmetic defect causes psychological trauma to a young patient. A comprehensive therapy with lifestyle changes, including balanced nutrition, exercise, behavioral education, and psychotherapy, as well as an individual approach to drug therapy is the main approach in the management of these patients. The article provides an overview of the most relevant and extensive global studies on this issue.