The nonrelativistic theory of nuclear matter (NM) based on Brussels-Skyrme interactions is employed to develop models for dense and neutron-rich matter within a Bayesian framework. We employ the following set of constraints: the four best-known nuclear empirical parameters, density dependence of the energy per particle in pure neutron matter (PNM), density dependence of the Landau effective mass (mₑff) of neutrons in PNM and symmetric NM, and a lower limit on the maximum gravitational mass that neutron stars (NSs) can sustain. In addition, a number of ``sanity checks'' are added: the values of the speed of sound, neutron and proton Landau effective masses and Fermi velocities are constrained up to the central density of the most massive NS configuration and for isospin asymmetries δ=(nₙ-nₚ)/(nₙ+nₚ) ranging from 0 to 1. Our ensemble of models fully explores the capacity of non-relativistic Brussels-Skyrme effective interactions to describe NM at densities exceeding several times the nuclear saturation density. This is a necessary step toward a better understanding of the properties of dense matter and possible correlations between the parameters of NSs and the parameters of NM. Due to pronounced U-shaped density-dependencies of mₑff, all our models exhibit a non-monotonic ``rise-and-fall'' behavior of the thermal pressure (pₜh) as a function of density, which in extreme cases leads to pₜh < 0. This work is a generalization of [Beznogov and Raduta, Phys. Rev. C 110, 035805 (2024)].
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