Is the oxytocin system a keystone in human wellbeing?

It has also taken over a century for science to fully realize that oxytocin is far more than a “female reproductive hormone.” Both the measurement and interpretation of the biochemical and functional properties of oxytocin have raised controversy and remain works in progress. However, oxytocin is now recognized as a pleiotropic molecule that sits at the center of an extended system which includes vasopressin, the autonomic nervous system, the immune system and more. This larger system affects essentially every bodily function and helps to coordinate these with social context, the history of each individual and perhaps the existence of humans as a species. Together these support survival, reproduction and wellbeing, allowing mammals to manage and benefit from various forms of hormetic challenge. Here we suggest that oxytocin, viewed as a system, in turn acts as a keystone capable of connecting mammalian regulatory physiology to the benefits of social connection.