Oncogenic KRAS Suppresses IFNγ Signaling in Tumor Cells

In this issue, Chen and colleagues show that MHC class II expression by pancreatic ductal adenocarcinoma (PDAC) malignant cells is a robust biomarker of both local production of IFNγ from lymphocytes and intact IFNγ signaling. RAS pathway inhibition can restore malignant cell IFNγ responsiveness in some patients, and malignant cell MHC class II expression may indicate which patients could further benefit from immunotherapy. See related article by Chen et al., p. XX .