Key result
Routine non-gated chest CTA reliably quantifies LV mass, identifying ~40% greater mass in aortic dissection.
Why the study?
Cardiac information within routine chest CTA for thoracic aortic disease remains underutilized, and the reliability of quantifying left ventricular myocardial mass from routine non-ECG-gated chest CTA needed evaluation.
Does automated three-dimensional segmentation of routine non-ECG-gated chest CTA reliably quantify left ventricular myocardial mass and detect differences in patients with thoracic aortic disease?
Observational (n=448)
Does automated three-dimensional segmentation of routine non-ECG-gated chest CTA reliably quantify left ventricular myocardial mass and detect differences in patients with thoracic aortic disease?
Routine non-ECG-gated chest CTA reliably quantifies left ventricular myocardial mass and identifies significant myocardial hypertrophy in patients with acute and chronic aortic dissection without requiring additional imaging or radiation.
Background: Routine chest computed tomography angiography (CTA) is the primary imaging modality for thoracic aortic disease, yet cardiac information within these examinations remains underutilized. We evaluated whether left ventricular myocardial mass (LVMM) can be reliably quantified from routine non-electrocardiographically (ECG)-gated chest CTA and its application in thoracic aortic pathology. Methods: CTA scans were obtained from 257 patients without aortic disease and 181 patients with thoracic aortic aneurysm or dissection. LVMM was quantified using automated three-dimensional segmentation. In a separate 10-patient validation cohort, LVMM was compared across end-systolic, end-diastolic, and non-ECG-gated source reconstructions. CTA-derived LVMM was compared with published echocardiographic and cardiovascular magnetic resonance (CMR) reference values using Cohen's d. Results: LVMM remained stable across cardiac phases and non-ECG-gated images (mean coefficient of variation, 2.4%), whereas left ventricular volume varied substantially (36.9%). CTA-derived LVMM demonstrated small effect sizes with the Penn method (d = 0.22) and moderate effect sizes with ASE linear (d = 0.67), area-length (d = 0.68), and CMR (d = 0.63). LVMM increased through young adulthood, with minimal association with age beyond 30 years. LVMM was comparable between patients with thoracic aneurysms and normal adults (140 ± 43 g vs. 141 ± 40 g; adjusted p = 1.0) but significantly greater in acute (199 ± 61 g) and chronic (191 ± 57 g) aortic dissection (both adjusted p < 0.001). Conclusions: Routine non-ECG-gated chest CTA enables reliable automated LVMM quantification without additional imaging or radiation and may facilitate large-scale investigations of ventricular remodeling in thoracic aortic disease.
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Twohig et al. (2026) conducted an observational in Thoracic aortic disease (thoracic aortic aneurysm or dissection) (n=448). Routine non-ECG-gated chest CTA with automated 3D segmentation vs. ECG-gated reconstructions, published echocardiographic and CMR reference values, and normal controls was evaluated on Left ventricular myocardial mass (LVMM) quantification reliability and comparison across thoracic aortic pathologies (Cohen's d 0.22 (vs Penn method), p=<0.001). Routine non-ECG-gated chest CTA reliably quantified LV myocardial mass (CV 2.4%), identifying greater mass in acute (199g) and chronic (191g) aortic dissection vs controls (141g; p<0.001).
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