Key result
Persistent complete AV block requires permanent pacing despite ~14-point LVEF recovery in Takotsubo syndrome.
Why the study?
Takotsubo syndrome, complete AV block, and acute extracardiac illness may coexist, obscuring their causal sequence.
Case Report (n=1)
No
In patients presenting with concurrent Takotsubo syndrome and complete atrioventricular block, electrical recovery cannot be inferred from ventricular systolic improvement, necessitating independent assessment of conduction for permanent pacing decisions.
AV block may persist despite LVEF recovery in Takotsubo; this case leaves open whether ventricular function predicts conduction recovery.
Takotsubo syndrome (TTS), complete atrioventricular (AV) block, and acute extracardiac illness may coexist, obscuring their causal sequence. A 64-year-old woman presented with severe epigastric pain and vomiting, high-sensitivity troponin of 340 ng/L peaking at 1,581 ng/L, B-type natriuretic peptide of 540 pg/mL, and high-grade AV block progressing to complete block. Echocardiography showed circumferential mid-apical akinesis with basal hyperkinesis and a left ventricular ejection fraction (LVEF) of 30%, while urgent coronary angiography demonstrated normal epicardial coronary arteries. Persistent gastrointestinal symptoms prompted abdominal computed tomography, which identified acute small bowel obstruction with concern for early bowel compromise. Bowel transit resumed with conservative treatment. Cardiac magnetic resonance showed apical ballooning and myocardial edema without perfusion defect or late gadolinium enhancement, supporting TTS. Before permanent pacing, LVEF improved to 44%, but complete AV block persisted with an intrinsic ventricular rate of 35–38 beats/min; a dual-chamber pacemaker was subsequently implanted. Small bowel obstruction may have triggered TTS, whereas the AV block may have been a consequence, an additional trigger, or pre-existing conduction disease. The early dissociation between partial myocardial recovery and persistent AV block shows that electrical recovery cannot be inferred from LVEF improvement and that pacing decisions require independent assessment of conduction.
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Khabote et al. (2026) conducted a case report in Takotsubo syndrome with complete atrioventricular block and acute small bowel obstruction (n=1). Dual-chamber permanent pacemaker implantation and conservative bowel management was evaluated on Myocardial recovery (LVEF) and atrioventricular conduction recovery at day 10. In a 64-year-old woman with Takotsubo syndrome and small bowel obstruction, LVEF improved from 30% to 44% by day 10 while complete AV block (35-38 bpm) persisted, requiring permanent pacing.
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