Key result
Higher relative fat mass is independently linked to reduced eGFR in hypertensive adults.
Why the study?
Obese individuals with comorbid hypertension have an elevated risk of chronic kidney disease, but whether relative fat mass can serve as an indicator of early renal dysfunction in hypertensive populations remained unclear.
Is elevated relative fat mass associated with reduced estimated glomerular filtration rate (<60 mL/min/1.73 m2) in community-dwelling adults with hypertension?
Cross-Sectional (n=4,439)
Is elevated relative fat mass associated with reduced estimated glomerular filtration rate (<60 mL/min/1.73 m2) in community-dwelling adults with hypertension?
Elevated relative fat mass is independently associated with reduced eGFR in community-dwelling hypertensive adults, suggesting its potential use as a low-cost anthropometric screening marker for early renal impairment.
Background: Obese individuals are at elevated risk of chronic kidney disease (CKD), particularly in the presence of comorbid hypertension, but whether relative fat mass (RFM) can serve as an indicator of early renal dysfunction in hypertensive populations remains unclear. Among community-dwelling adults with hypertension in Jiangsu Province, China, we evaluated the relationship between RFM and estimated glomerular filtration rate (eGFR). Methods: We recruited 4439 adults with hypertension and defined reduced eGFR as <60 mL/min/1.73 m2. Multivariable logistic regression, subgroup analyses, restricted cubic spline (RCS) modeling, and receiver operating characteristic (ROC) curve analysis were used. Results: In total, 1474 participants (33%) had reduced eGFR. Each unit increase in RFM was marginally associated with higher odds of reduced eGFR after multivariable adjustment; adjusted odds increased across RFM quartiles and reached significance in Q3 and Q4. RCS analysis indicated an approximately linear association, and RFM yielded an area under the curve (AUC) of 0.630 for identifying reduced eGFR. Conclusions: Elevated RFM is independently associated with reduced eGFR in community-dwelling hypertensive adults, supporting its potential utility as a low-cost and readily accessible anthropometric marker for early screening of renal impairment in primary care.
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Xie et al. (2026) conducted a cross-sectional in Hypertension (n=4,439). Relative fat mass (RFM) vs. Lower quartiles of relative fat mass was evaluated on Reduced estimated glomerular filtration rate (eGFR <60 mL/min/1.73 m2). Relative fat mass was independently associated with reduced eGFR (<60 mL/min/1.73 m2) in hypertensive adults, yielding an AUC of 0.630.
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