GeneXpert MTB/RIF detects only rifampicin resistance. A 19‐year‐old man with cough and haemoptysis had rifampicin‐susceptible tuberculosis on bronchoalveolar lavage Xpert. Phenotypic drug susceptibility testing later revealed isolated isoniazid resistance, and isoniazid was replaced with levofloxacin. Additional susceptibility testing is essential to detect isoniazid‐resistant, rifampicin‐susceptible tuberculosis.
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Nadeem et al. (2026) studied this question.
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