Standardization of Medicinal Plant Raw Materials: Calendulae flos in the State Pharmacopoeia of Ukraine and Český Lékopis

The article presents a comparative analysis of the quality indicators of medicinal plant raw materials Calendulae flos according to the monographs of the State Pharmacopeia of Ukraine and Český Lékopis. Macroscopic and microscopic characteristics, methods for identifying biologically active compounds, approaches to the quantitative determination of flavonoids, as well as regulatory requirements for moisture, ash content and impurities are considered. Found that both pharmacopoeias have a high level of consistency in key parameters, but differ in the detail of the description and the severity of control standards: State Pharmacopeia of Ukraine is focused on the accessibility and practicality of methods, while Český Lékopis is focused on accuracy and unification in accordance with European standards. The importance of harmonizing pharmacopoeial requirements for international pharmaceutical practice and increasing the competitiveness of herbal medicines on the global market is emphasized. A promising direction for further research is the use of standardized preparations of calendula officinalis as adjuvants in the therapy of tuberculosis, given their anti-inflammatory, antioxidant, and immunomodulatory properties.