Key result
Abdominal obesity with endothelial and circadian dysfunction linked to ~60% higher 24-hour systolic BP variability.
Why the study?
Does the combination of abdominal obesity, endothelial dysfunction, and circadian blood pressure rhythm disturbances impair cardiovascular functional parameters (blood pressure variability and endothelial function) in adults aged 28–59 years?
Cross-Sectional (n=88)
No
Does the combination of abdominal obesity, endothelial dysfunction, and circadian blood pressure rhythm disturbances impair cardiovascular functional parameters (blood pressure variability and endothelial function) in adults aged 28–59 years?
Non-invasive assessment of brachial artery flow-mediated dilation and 24-hour ambulatory blood pressure monitoring identifies distinct cardiovascular risk phenotypes, showing that endothelial dysfunction and circadian blood pressure disturbances drive blood pressure variability more strongly than obesity alone.
Background. Despite the wide prevalence of abdominal obesity, the functional characteristics of the cardiovascular system under different combinations of obesity with endothelial dysfunction and circadian blood pressure rhythm disturbances remain insufficiently studied. The aim of the study was to evaluate functional parameters of the cardiovascular system in individuals with different combinations of abdominal obesity, endothelial dysfunction, and circadian blood pressure (BP) rhythm disturbances, using exclusively non-invasive examination methods. Methods. A total of 88 individuals aged 28–59 years were examined. Body mass index (BMI) was determined, and 24-hour ambulatory blood pressure monitoring (ABPM) was performed to assess circadian rhythm and BP variability. Endothelial function was evaluated by flow-mediated dilation (FMD) of the brachial artery during a reactive hyperemia test. Data normality was verified by the Shapiro–Wilk test. Results. Four groups of subjects were identified based on a combination of three criteria. A progressive deterioration of functional parameters was established from group A (no obesity, no functional disturbances) to group D (obesity combined with endothelial dysfunction (ED) and disturbed circadian rhythm): systolic BP (SBP) variability increased by 60 % (p < 0.05), and the frequency of ED rose from 14 % to 73 %. Notably, individuals with obesity and preserved endothelial function (group C) had a lower frequency of ED (27 %) than individuals without obesity but with functional disturbances (group B – 52 %). Conclusions. The combination of abdominal obesity with endothelial dysfunction and disturbed circadian blood pressure rhythm is associated with the most pronounced impairment of the adaptive capacity of the circulatory regulation system. Non-invasive assessment of endothelial function and circadian BP rhythm makes it possible to identify groups of individuals with different degrees of functional risk without the use of invasive investigations.
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Tp et al. (2026) conducted a cross-sectional in Abdominal obesity, endothelial dysfunction, and circadian blood pressure rhythm disturbances (n=88). Abdominal obesity combined with endothelial dysfunction and disturbed circadian blood pressure rhythm (Group D) vs. No obesity and no functional disturbances (Group A) was evaluated on 24-hour systolic blood pressure variability (%) (p=<0.05). Abdominal obesity combined with endothelial dysfunction and circadian BP disorders increased 24-hour systolic BP variability by 60% (38.92% vs 24.31%, p<0.05) compared to healthy controls.
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