Borrelia burgdorferi polymerase chain reaction (PCR) testing demonstrated a low positivity rate of 1.9% (17/885), minimal impact on clinical decision-making, and considerable healthcare cost expenditures in a Lyme disease endemic area. These findings reinforce adherence to guideline-recommended serologic testing and support diagnostic stewardship initiatives to limit unnecessary PCR utilization.
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Kufel et al. (2026) studied this question.
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