Answers are grounded in this paper and cite their sources.
A research field records its open problems in surveys, keynotes and community reports. Those are prose, written every few years, and nobody can ask them who works on a problem now or whether it was settled last year. We argue the problems should be data, and we build the system that makes them so: a hand-curated problem layer carried in unchanged, under an evidence layer rebuilt from a bibliographic index, joined by typed, provenance-carrying links in one graph database and queryable from one language. A language model does four jobs -- per-paper extraction, catalog grounding, per-paper status verdict, and idea generation -- each constrained to a candidate set so out-of-set answers are refused rather than stored. We report a study on two curated catalogs, database research (1,053 problems) and AI research (1,000 problems), each with a prior catalog-only graph. The rebuilt graph answers every question the catalog-only graph answered -- 47 of 47 on databases, 34 of 35 on AI -- plus questions the catalog-only graph refused: recent workers, untouched problems, methods tried, and outside papers bearing on a problem (336 problems, 770 works on databases). The capability we most wanted does not survive its own audit. Of 41 solves and refutes verdicts hand-checked against the papers, 9 are correct, 30 partly correct and 2 wrong; no refutes verdict (0 of 34) disproves an open problem, and only 1 of 7 solves closes the central question. We report that failure in full and draw the design conclusion: a status change must be proposed with its evidence and never applied, making the human reviewer part of the architecture. We close with the data-engineering problems this raises: entity resolution across curated and harvested layers, verifying model status claims, freshness under source quotas, and evaluation without ground truth.
No takes yet. Share an insight, caveat, or question.
Mandarapu et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: