Outcomes of Pylorus-Preserving Pancreaticoduodenectomy for Periampullary Carcinoma in a Hepatobiliary Unit of A Military Hospita

Objective: To evaluate the outcome of pylorus-preserving pancreaticoduodenectomy for periampullary carcinoma in the hepatobiliary unit. Study Design: Prospective analytical study Place and Duration of study: Pak-Emirates Military Hospital, Rawalpindi, Pakistan, from Jun 23 to Feb 24 Methodology: Fifty-five consecutive patients with periampullary carcinoma underwent PPPD or Whipple procedure. A non-probability consecutive sampling technique was applied. Data were collected on the patients' demographics, intraoperative factors, pathology, and postoperative outcomes, including blood loss, hospital stay, complications, mortality, and weight changes. Results: Of the 55 patients, 58.18% were male. Their mean preoperative weight was 70.07+ 7.91 kg, and their mean age was 59.32 + 7.03 years. Groups A and B had substantially different intraoperative blood loss (p< 0.05) and procedure durations (244.28 ± 44.59 ml; 337.86 ± 32.92min) and 351.48 ± 48.57ml; 342.22+49.33 min). Relaparotomy, delayed stomach emptying, and positive resection margins were among the post-surgery complications rates that did not significantly differ between groups (p> 0.05). Group-A's mortality rate was 17.8%, whereas Group-B's was 11.11% (p = 0.478). Conclusion: Our findings suggest that, in cases with periampullary malignancy, pylorus-preserving pancreaticoduodenectomy is a preferable option to the Whipple approach, since it minimizes perioperative problems and enhances postoperative quality of life. To improve surgical methods and patient selection, further research is required.