Machine Learning Perspectives in Smart Healthcare: Challenges, Opportunities, and Applications This research paper explores the growing role of Machine Learning (ML) in transforming modern healthcare systems through intelligent data analysis, predictive modeling, and clinical decision support. The study examines various machine learning architectures, including Convolutional Neural Networks (CNNs), Recurrent Neural Networks (RNNs), Long Short-Term Memory (LSTM), and Transformer-based models, along with their applications in medical diagnosis and patient monitoring. It also highlights major challenges in implementing ML in healthcare, such as algorithmic bias, limited medical datasets, data privacy, model reliability, and healthcare data interoperability. Furthermore, the paper proposes a unified four-pillar evaluation framework focusing on predictive robustness, explainability, data transparency, and privacy and governance. The research emphasizes the importance of developing reliable, transparent, and secure machine learning systems to improve healthcare decision-making and patient safety. Research Areas: Machine Learning, Smart Healthcare, Artificial Intelligence, Deep Learning, Medical Informatics, Predictive Analytics, Data Privacy, and Healthcare Technology. Authors: Samadhan Babasaheb Sangale, Siddhesh Bhausaheb Sangle, and Vaishnavi Janu Rokde. Institution: Sandip Institute of Engineering and Management (SIEM), Sandip Foundation, Nashik, Maharashtra, India.
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Sangle et al. (2026) studied this question.
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