Key result
Magnetic field therapies modulate cardiac electrophysiology and autonomic tone preclinically, but clinical data remain scarce.
Why the study?
Magnetic fields offer noninvasive deep tissue penetration and controllability for modulating cardiovascular function, yet clinical validation is limited and translational bottlenecks such as parameter standardization and long-term safety remain.
Do noninvasive magnetic field-based interventions and magnetic-responsive materials modulate cardiac electrophysiology, autonomic balance, and tissue repair to improve outcomes in cardiovascular diseases such as arrhythmias, myocardial infarction, and heart failure?
Do noninvasive magnetic field-based interventions and magnetic-responsive materials modulate cardiac electrophysiology, autonomic balance, and tissue repair to improve outcomes in cardiovascular diseases such as arrhythmias, myocardial infarction, and heart failure?
This review synthesizes how noninvasive magnetic fields and magnetic-responsive nanomaterials can reversibly modulate cardiac electrophysiology, autonomic tone, and myocardial repair, while highlighting that clinical translation currently rests on a single small randomized trial for ventricular tachycardia storm and requires parameter standardization and long-term safety validation.
Preclinical cardiac modulation by magnetic fields merits cautious exploration; leaves open clinical adoption pending larger RCTs and parameter standardization.
Cardiovascular diseases remain the leading cause of death worldwide, and their burden continues to rise. As a noninvasive physical intervention, magnetic fields offer deep tissue penetration, remote programmability, and favorable spatiotemporal controllability, making them uniquely valuable for modulating cardiovascular function. This review systematically summarizes the biological basis of magnetic field actions on the cardiovascular system, including multi-scale effects on cardiac electrophysiology and ion channels, vascular endothelial function and microcirculatory perfusion, and cardiac autonomic regulation. On this basis, we synthesize therapeutic advances in three areas: electrophysiological intervention in arrhythmias, cardiac autonomic neuromodulation, and cardiac repair and regeneration. Preclinical evidence indicates that magnetic fields can mediate nonpharmacological intervention in arrhythmias, myocardial infarction, and heart failure, although clinical validation to date is limited to a single small randomized trial. Finally, we analyze translational bottlenecks (standardization of stimulation parameters, long-term in vivo safety assessment, and intelligent closed-loop control) and outline future directions integrating magnetic fields with regenerative medicine and artificial intelligence, aiming to provide new strategies for precision cardiovascular care.
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孔德汶 et al. (2026) conducted a review in Cardiovascular diseases (arrhythmias, myocardial infarction, and heart failure). Magnetic field-based interventions (direct electromagnetic fields and magnetic-responsive materials/transducers) was evaluated. Magnetic field-based interventions modulate cardiac ion channels, endothelial function, and autonomic tone in preclinical models, though clinical validation is limited to one small RCT (n=26).
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