Pretreatment Factors Associated With Response to Eruption Guidance Appliance Therapy in Class II Division 1 Malocclusion: A Preliminary Pilot Study

PurposeThe purpose of this study is to identify pretreatment factors associated with response to eruption guidance appliance (EGA) therapy in growing patients with Class II Division 1 malocclusion. MethodsA retrospective cephalometric study was conducted on 12 growing patients treated with a Multi-P eruption guidance appliance.Standardized lateral cephalograms obtained before treatment (T1) and after treatment (T2) were analyzed.Simple linear regression analyses were performed to investigate the association between pretreatment demographic, cephalometric, and occlusal variables and improvement in the A point-nasion-B point (ANB) angle. ResultsYounger age at treatment initiation demonstrated the strongest association with ANB angle improvement (R 2 =0.556; p=0.005).In addition, greater pretreatment overjet (R 2 =0.492; p=0.011), a higher Jarabak ratio (R 2 =0.459; p=0.015), a lower Y/SN angle (R 2 =0.445; p=0.018), and a higher sella-nasion-A point (SNA) angle (R 2 =0.335; p=0.048) were also significantly associated with greater sagittal improvement.Conversely, pretreatment ANB, pretreatment sella-nasion-B point (SNB), overbite, and treatment duration were not significantly associated with treatment response. ConclusionPretreatment age, craniofacial morphology, and overjet were associated with response to EGA therapy in growing patients with Class II Division 1 malocclusion.These findings may help clinicians identify patients more likely to benefit from interceptive orthodontics and support individualized treatment planning.Further prospective studies with larger samples are required to confirm these findings.