Acute fulminant Clostridium-Perfrigens sepsis with massive intravascular hemolysis in a young woman with sickle cell disease. Case presentation and review of the literature

To the Editor Sickle cell disease (SCD) is an inherited hemoglobinopathy caused by a single amino acid substitution at the sixth residue of the beta (β)-globin subunit (p.Glu6Val) Vaso-occlusion, hemolytic anemia and vasculopathy are the hallmarks of SCD pathophysiology, leading to high morbility and mortality.