Prevalence of Antiphospholipid Antibodies Among Pregnant Women Attending Antenatal Clinic in Usmanu Danfodio University Teaching Hospital Sokoto Nigeria

phospholipids and phospholipid binding Antiphospholipid Antibodies (Apl) are a group proteins (Comarmond et al., 2013).However, of auto antibodies that bind to negatively charged the most important clinically are the Lupus phospholipids and have been associated with Anticoagulant (La) and Anticardiolipin thrombotic events.approximately 50-70% of Antibodies (Acl).Even though these antibodies pregnant women with Apl may end up with an have been found in individuals without any obstetric complication which include recurrent clinical consequences, approximately 15-20% pregnancy loss, pre-eclampsia, intrauterine of patients with these antibodies have obstetric foetal death, preterm delivery and low birth complications and up to 50-75% of these weight.The aim of this study was to determine pregnancies have poor outcomes (Andreoli et the prevalence of antiphospholipid antibodies in al., 2013).Some of these obstetric complications the second half of pregnancy in the study area.are recurrent pregnancy loss, unexplained This study is a prospective cohort study that was intrauterine foetal death, preterm deliveries, and carried out on four hundred and twenty-seven severe pre-eclampsia.Lupus anticoagulant (La) pregnant women presenting to the antenatal was found to be autoantibodies that reacted with clinic of Usmanu Danfodiyo University negatively charged phospholipids, and in doing Teaching Hospital.Blood samples was taken so prolonged the in vitro clotting time in under aseptic technique for Lupus Anticoagulant phospholipid-dependent coagulation assays, (La) and Anticardiolipin (Acl) Immunoglobulin such as the activated partial thromboplastin time G (IgG) And Immunoglobulin M (IgM) and the dilute Russell viper venom time.estimation was carried out using the ELISA technique.The prevalence of antiphospholipid A recent systematic review by Vrziæ and antibodies was found to be about 6.6% (29).The Coworkers (2023), showed strong in vitro types of Antiphospholipid antibodies evidence that Apl detrimentally affect encountered were anticardiolipin 3.5% (15), trophoblast syncytialization, viability and Lupus Anticoagulant 2.8% (12) and 0.7% (3) had invasion and further, disrupts molecular both.The prevalence of antiphospholipid signaling mechanisms in the trophoblasts and antibody in pregnant women attending ANC at increase inflammation and coagulation on the UDUTH Sokoto was low.cell surface.