The Role of Gender, Age and Medical Activities in the Effectiveness of Helicobacter Pylori Eradication

The aim of the research . Analysis of the results of Helicobacter pylori (H. pylori) treatment with the firstline regimen and bismuth in residents of the Transbaikal region depending on gender, age and medical activity. Materials and methods . H. pylori eradication was performed using a first-line regimen (proton pump inhibitor, clarithromycin, amoxicillin) and bismuth tripotassium dicitrate at recommended doses for 14 days in 116 people. Of these, 82 were women and 34 were men, 59 were aged 20–50 years and 57 were aged 51– 65 years, 52 were medical staff and 64 were non-medical. Eradication control was performed 6–8 weeks after treatment with H. pylori antigen in feces using immunochromatographic analysis. During treatment, adverse events (AE) were analyzed. Statistical methods : descriptive statistics, x2-test, odds ratio (OR) (biostatistics). Results. The efficiency of H. pylori eradication in the study group was 71,5%, among medical staff – 57,7%, among non-medical – 82,8% (p = 0,003). More successful treatment was observed among female non-medical (92,1%), in contrast to male non-medical (69,2%, p = 0,018) and female medical staff (52,3%, p < 0,001).Non-medical aged 20–50 demonstrated the best eradication results – 93,3%, patients aged 51–65 nonmedical – 73,5% (p = 0,037), medical staff aged 20–50 – 58,6% (p = 0,002). There were no gender or age differences in the group of medical staff. AE were registered in 64 people (55,2%): 35 (67,3%) medical staff and 29 (45,3%) non-medical. AE were 2,5 times more common in male medical staff than in men in other specialties (p = 0,009). Conclusion . Probability of H. pylori eradication is higher in women under 50 years of age who are not medically active. H. pylori eradication is less common in medical staff with-out gender or age differences, with a higher incidence of AE, especially in men.