Answers are grounded in this paper and cite their sources.
A macrocyclic olefin metathesis approach to marchantin A was explored. The diene precursor was successfully assembled via two sequential Ullmann reactions. however, the subsequent ring-closing metathesis exclusively afforded the dimeric product. Furthermore, the biological evaluation of the intermediates and intermediate-derived analogues revealed that compounds 27 and 30 exhibited potent cytotoxicity against HCT116 cell line, with IC50 values of 9.52 µM and 2.87 µM, respectively.
No takes yet. Share an insight, caveat, or question.
Lu et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: