Bisdemethoxycurcumin Attenuates Sciatic Nerve Injury in Vincristine- Induced Neuropathic Pain Mice

Background Chemotherapy-induced neuropathic pain is a common side effect for cancer patients. There are many therapeutic choices available today, but they typically have negative side effects and are ineffective at reducing pain. As a result, novel strategies for treating chemotherapy induced neuropathic pain are being investigated, particularly those involving natural substances. Bisdemethoxycurcumin (BDCM), a component of turmeric, is a potential target. This study explores the potential of BDCM in lessening pain sensitivity and restoring sciatic nerve damage. Methodology Mice were injected with vincristine sulfate intraperitoneally to create the study model. The cold plate test, thermal radiation test, and Von Frey test were used to evaluate the potential pain-relieving benefits of BDCM. We employed transmission electron microscopy (TEM), hematoxylin and eosin staining, silver staining, and an electrophysiological stimulation test to assess BDCM's possible neuroprotective effect on the sciatic nerve. We further evaluated BDCM’s effects on NF-κB and pro-inflammatory cytokines. Results BDCM treatment reduced the frequency of paw lifts, increased the latency before paw withdrawal, and significantly raised the paw withdrawal threshold. BDCM reduced sciatic nerve tissue damage and increased sensory nerve conduction velocity. Additionally, BDCM decreased NF-κB and pro-inflammatory cytokines expression. Conclusion These findings demonstrate that BDCM alleviates VCR-induced sciatic nerve damage and preserves nerve integrity, highlighting its potential as a novel therapeutic agent for neuropathic pain and further studies should further explore its mechanisms in neuropathic pain attenuation.