Modern approaches to rehabilitation of patients with heart failure. Prospects for using the interval hypoxic-hyperoxic training method

Q: What is the clinical evidence from this study?

Study design: Review. Population: Chronic heart failure (CHF) and acute decompensated heart failure (ADHF). Intervention: Interval hypoxic-hyperoxic training (IHHT / re-oxy therapy) vs. Standard cardiac rehabilitation or control group without re-oxy therapy. Primary outcome: Exercise tolerance (6-minute walk test), hemodynamic and metabolic parameters, and safety.

Q: What does this research mean for the field?

Interval hypoxic-hyperoxic training is a promising cardiac rehabilitation strategy that improves clinical parameters and exercise tolerance in patients with chronic heart failure, although larger randomized trials are needed to confirm efficacy and safety. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Сахарчук Алексей Юрьевич; Н. Б. Лебедева

doi:10.23946/2500-0764-2026-11-1-74-81

March 22, 2026Fundamental and Clinical MedicineOpen Access

Modern approaches to rehabilitation of patients with heart failure. Prospects for using the interval hypoxic-hyperoxic training method

View Full Paper

Ask AI

Bookmark

Share

Key result

Interval hypoxic-hyperoxic training safely improves exercise tolerance and hemodynamics in heart failure rehabilitation.

Why the study?

This review aimed to analyze modern approaches to rehabilitation and evaluate the possibilities and prospects of using interval hypoxic-hyperoxic training in patients with CHF.

Does interval hypoxic-hyperoxic training improve exercise tolerance, hemodynamic and metabolic parameters, and rehabilitation outcomes in patients with heart failure?

Key Points

To analyze modern rehabilitation approaches and evaluate the potential and prospects of interval hypoxic-hyperoxic training (IGTT) in patients with chronic heart failure.
Literature review of scientific publications indexed in elibrary.ru and PubMed between 2014 and 2024.
Searches utilized keywords including hypoxic effects, interval hypoxic training, hypoxic-hyperoxytherapy, re-oxy therapy, pathophysiological mechanisms of hypoxia, and cardiorehabilitation.
Inclusion criteria encompassed randomized trials, systematic reviews, and original controlled clinical studies.
Interval hypoxic-hyperoxic training exhibits a sound pathophysiological basis and demonstrates positive therapeutic outcomes across published clinical studies.
Current evidence highlights IGTT as a promising rehabilitative strategy, though practical integration and adoption require large randomized trials to definitively confirm clinical efficacy and safety.

Structured PICO

Does interval hypoxic-hyperoxic training improve exercise tolerance, hemodynamic and metabolic parameters, and rehabilitation outcomes in patients with heart failure?

P

Population

Patients with chronic heart failure and acute decompensated heart failure undergoing cardiac rehabilitation, evaluated through a review of studies published between 2014 and 2024.

I

Intervention

Interval hypoxic-hyperoxic training (IHHT / re-oxy therapy), typically using a hypoxic gas mixture of 12-13% O2 for 3-5 minutes alternating with a hyperoxic gas mixture of 35-40% O2 for 1-3 minutes, for a total procedure duration of 40-45 minutes (course of 10-14 days in post-CABG patients).

C

Comparator

Standard cardiac rehabilitation / physical training or treatment without re-oxy therapy.

O

Outcome

Exercise tolerance (6-minute walk test), hemodynamic parameters (heart rate, systolic and diastolic blood pressure), metabolic markers (cholesterol, glucose), natriuretic peptide levels, and clinical safety.surrogate

Interval hypoxic-hyperoxic training is a pathophysiologically grounded, promising non-pharmacological adjunct or alternative to physical exercise for cardiac rehabilitation in heart failure patients, warranting large-scale randomized trials.

Limitations

Relatively small number of large randomized and multicenter studies on interval hypoxic-hyperoxic training
Contraindicated in patients with active inflammatory processes and severe oncological diseases
Duration of the training course in practice may be longer than the length of hospitalization
Requires careful monitoring in the presence of a physician due to initially low oxygen saturation in heart failure patients
Relatively small number of large randomized and multicenter studies on IHHT
Contraindications include active inflammatory processes and severe oncological diseases
Duration of the training course may exceed the length of hospital stay
Requires continuous medical supervision due to low baseline oxygen saturation and potential risks of acute respiratory failure, arrhythmias, or local ischemia

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Shows promise in HF rehabilitation; leaves open confirmation by large RCTs.

Abstract

Aim. The purpose of this review is to analyze modern approaches to rehabilitation and evaluate the possibilities and prospects of using the method of interval hypoxic-hyperoxic training (IGTT) in patients with CHF. Materials and methods . Analysis of scientific publications presented in databases elibrary.ru PubMed was conducted for the period from 2014 to 2024 on keywords such as "hypoxic effects, interval hypoxic training, hypoxic-hyperoxytherapy, re-oxy therapy, pathophysiological mechanisms of hypoxia, cardiorehabilitation." The inclusion criteria were the results of randomized trials, systematic reviews, as well as original articles with a control group. Results. It has been shown that the IGTT method is a promising direction that has a pathophysiological basis and demonstrates positive results in clinical trials. Conclusions. Further development and practical integration of this method require large randomized trials to confirm its clinical efficacy and safety.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Юрьевич et al. (2026) conducted a review in Chronic heart failure (CHF) and acute decompensated heart failure (ADHF). Interval hypoxic-hyperoxic training (IHHT / re-oxy therapy) vs. Standard cardiac rehabilitation or control group without re-oxy therapy was evaluated on Exercise tolerance (6-minute walk test), hemodynamic and metabolic parameters, and safety. Interval hypoxic-hyperoxic training safely improves exercise tolerance, heart rate, blood pressure, and natriuretic peptide levels in heart failure rehabilitation, though large RCTs are needed.

synapsesocial.com/papers/6aeb887a46156a9a55c77a3e https://doi.org/10.23946/2500-0764-2026-11-1-74-81

View Full Paper

Ask AI

Bookmark

Share

Modern approaches to rehabilitation of patients with heart failure. Prospects for using the interval hypoxic-hyperoxic training method

Key Points

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Modern approaches to rehabilitation of patients with heart failure. Prospects for using the interval hypoxic-hyperoxic training method

Key Points

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading