Key result
Pregnancy with tetralogy of Fallot linked to ~15-point higher arrhythmia risk than other congenital heart disease.
Why the study?
Tetralogy of Fallot is associated with maternal-fetal risks during pregnancy, particularly in individuals with uncorrected or residual defects.
Does tetralogy of Fallot increase the risk of maternal cardiac and adverse perinatal outcomes compared to other congenital heart diseases in pregnant individuals?
Cohort (n=39,473)
Does tetralogy of Fallot increase the risk of maternal cardiac and adverse perinatal outcomes compared to other congenital heart diseases in pregnant individuals?
Pregnant individuals with tetralogy of Fallot experience significantly higher rates of maternal arrhythmias, endocarditis, and preterm delivery compared to pregnant individuals with other congenital heart diseases, highlighting the need for specialized cardio-obstetric surveillance.
Answers are grounded in this paper and cite their sources.
Supports heightened cardio-obstetric rhythm and perinatal surveillance in pregnant patients with tetralogy of Fallot; leaves open whether targeted interventions reduce these excess risks.
Background Tetralogy of Fallot (TOF) is associated with maternal-fetal risks during pregnancy, particularly in those with uncorrected or residual defects. Methods This retrospective cohort study identified pregnancies with TOF and compared them with pregnancies with other congenital heart diseases (CHDs) using ICD-10 codes, between 5/23/22 and 5/22/25. Demographic and clinical characteristics were analyzed using analysis of variance or Student’s t -tests for continuous variables and chi-square tests for categorical variables. Results There were 1574 women (1961 pregnancies) with TOF compared to 37,899 women (47,239 pregnancies) with other CHD. Significant differences in cardiac outcomes were observed in arrhythmias (32.9% vs. 18.3%), particularly ventricular arrhythmias (6.8% vs. 2.1%) and endocarditis (2.4% vs. 1.5%). Significant perinatal outcomes included preterm delivery (17% vs. 14.1%) and earlier gestational age at delivery (37.4 ± 3 vs. 38.9 ± 1.7). Conclusions Pregnancies with TOF have a greater occurrence of adverse cardiac outcomes, particularly arrhythmias and endocarditis, and obstetric outcomes, including preterm delivery.
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Patel et al. (2026) conducted a cohort in Pregnant individuals with tetralogy of Fallot or other congenital heart diseases (n=39,473). Tetralogy of Fallot (TOF) in pregnancy vs. Other congenital heart diseases (CHDs) in pregnancy was evaluated on Arrhythmias. Pregnancies with tetralogy of Fallot had higher rates of arrhythmias (32.9% vs 18.3%), endocarditis (2.4% vs 1.5%), and preterm delivery (17% vs 14.1%) than those with other congenital heart diseases.
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