Key result
High China-PAR cardiovascular risk is linked to ~0.7-point lower MoCA cognitive scores.
Why the study?
This study was conducted to investigate the association between cardiovascular disease risk and cognitive function in older adults using the China-PAR model.
Is higher cardiovascular disease risk estimated by the China-PAR model associated with poorer cognitive function (lower MoCA scores) in older Chinese adults?
Cross-Sectional (n=570)
Stratified random sampling
No
Is higher cardiovascular disease risk estimated by the China-PAR model associated with poorer cognitive function (lower MoCA scores) in older Chinese adults?
Higher 10-year cardiovascular disease risk estimated by the China-PAR model is independently associated with lower cognitive function scores on the MoCA among community-dwelling older adults in China.
Answers are grounded in this paper and cite their sources.
Higher China-PAR risk was associated with modestly lower MoCA scores; hypothesis-generating for longitudinal studies on risk modification and cognition.
Objective To investigate the association between cardiovascular disease (CVD) risk and cognitive function in older adults using the China-PAR model. Methods This study adopted stratified random sampling. A total of 570 older adults were selected from 3,750 health examinations at a community health service station, with sample size calculated by the cross-sectional study formula. We collected questionnaire and physical examination data including demographics, blood pressure and metabolic indicators. Cognitive function was measured by the Montreal Cognitive Assessment (MoCA), and cardiovascular risk was assessed via the China-PAR model. All analyses were performed with SPSS 27.0 using Spearman's rank correlation analysis and multiple linear regression analysis. Results The mean MoCA score was 25.94 ± 2.71. MoCA scores differed significantly across CVD risk groups and were negatively correlated with CVD risk level (r = −0.56, p < 0.001). In the primary adjusted Model 2, both the high-risk (B = −0.68, p < 0.001) and moderate-risk groups (B = −0.31, p = 0.02) had significantly lower MoCA scores than the low-risk group. In the sensitivity analysis (Model 3) additionally adjusting for age and gender, the results were similar (high risk: B = −0.65, p < 0.001; moderate risk: B = −0.30, p = 0.03). Compared with the college group, all lower education groups showed significantly lower MoCA scores. Sensitivity analyses restricted to participants aged ≤ 74 years yielded a similar pattern of findings. Conclusion Higher CVD risk was associated with poorer cognitive function in this study population, with lower MoCA scores observed particularly among participants in the high-risk group. Given the cross-sectional design, longitudinal studies are needed to clarify the temporal relationship between CVD risk and cognitive function.
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Liu et al. (2026) conducted a cross-sectional in Cardiovascular disease risk and cognitive function in older adults (n=570). High 10-year cardiovascular disease risk (≥10%) on China-PAR model vs. Low 10-year cardiovascular disease risk (<5%) on China-PAR model was evaluated on Total Montreal Cognitive Assessment (MoCA) score (B -0.68, 95% CI -0.98 to -0.39, p=<0.001). High China-PAR cardiovascular disease risk was significantly associated with lower MoCA cognitive scores compared to low risk (adjusted B = -0.68, p < 0.001) in older adults.
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