May-Thurner Syndrome Presenting as Submassive Pulmonary Embolism in a Young Male: A Case Report

May-Thurner syndrome (MTS) is an anatomic variant in which the right common iliac artery compresses the left common iliac vein, predisposing to left lower extremity deep vein thrombosis (DVT).While MTS predominantly affects young women, we present a case of a 24-year-old African American male with a family history suggestive of hereditary hypercoagulability who developed a massive bilateral pulmonary embolism (PE) with right heart strain and extensive left lower extremity DVT, revealing underlying MTS as the anatomic substrate for his thrombotic event.Management included systemic anticoagulation, mechanical pulmonary thrombectomy, and percutaneous lower extremity thrombectomy, with plans for outpatient hypercoagulability evaluation.