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A modular apurinic/apyrimidinic (AP)/Exo-Cas12 toolbox integrates cell selection enrichment with AP-repair pathways or exonucleases for plant editing. It achieves efficient multiplex genome editing and easily detectable large DNA deletions in rice, providing a robust platform for multigene knockouts and crop improvement.
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Chai et al. (2026) studied this question.
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