Selection of candidate dermatophytic strains for designing of new vaccines against animal dermatophytoses

The article covers a selection method of dermatophyte fungi on the basis of their sporulation and populational stability in order to derive a highly productive vaccine strains. Twenty wild strains of Microsporum canis from the collection of FSC VIEV RAS were primary studied, from which strain M. canis No. 5 was chosen for further selection. After three stages of selection, the sporogenicity was intensified up to 127 millions of microconidia/ml, which is four times higher than that of the original variant. This method of selection can be used to develop a platform for designing new vaccines against fungal infections in animals, including dermatophytosis and opportunistic mycoses. It makes it possible to obtain highly productive and stable vaccine strains of fungi.