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The application of plant-based bioactive nanoparticles in antifertility research offers a novel and promising approach to contraceptive development. This review examines the extensive potential of various medicinal plants and their bioactive compounds in nanoparticles as effective antifertility agents. Plant-based nanoparticles provide a significant advantage over traditional synthetic contraceptives due to their biocompatibility, reduced side effects, and ability to target specific tissues or cells. This review examines the various mechanisms through which these nanoparticles exert their antifertility effects, including hormonal modulation, disruption of spermatogenesis, and inhibition of fertilisation. The safety profiles, efficacy studies, and potential for integration with existing contraceptive methods are also discussed. By leveraging the inherent benefits of nanotechnology, plant-based bioactive nanoparticles hold the promise of revolutionising contraceptive technology, offering safer, more effective, and sustainable solutions to meet the growing global demand for contraceptives.
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Bharti et al. (2025) studied this question.
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