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By sensing local conformational strains in DNA, Taq MutS utilizes a push-pull mechanism via the synergy of residues S57 and D472 to modulate π-stacking interactions between the key recognition residue F39 and DNA, thereby achieving specific mismatch-site recognition. Meanwhile, residues K61 and R473 fine-tune non-specific binding of Taq MutS through electrostatic synergy.
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Jiang et al. (2026) studied this question.
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