Adolescents’ Depression, Anxiety, Stress, Suicidal Ideation, and Suicide Prevention: A Systematic Review

Mental health problems among adolescents are on the rise and are currently among the most common causes of illness, disability, and even mortality. Common mental health problems among adolescents include depression, anxiety, stress, and suicidal ideation, which can contribute to suicide if not detected and treated early. This systematic review aimed to identify and evaluate the effectiveness of mental health and suicide prevention programs among adolescents. The review was conducted by searching databases such as Web of Science, Scopus, ScienceDirect, and PubMed following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis checklist. All peer-reviewed, research-based articles published in English between 2015 and 2025 that addressed prevention programs targeting adolescents were included, resulting in 23 eligible studies from 16 946 screened records. The review protocol was registered in the Open Science Framework. Overall, 16 of the 23 studies indicated that prevention programs, 10 delivered face-to-face and 6 delivered online, showed a positive trend toward reduced mental health problems and suicide among adolescents. However, some findings did not reach statistical significance. This systematic review suggests that the diversity of programs made it difficult to identify any single program as the gold standard for reducing mental health problems and suicide among adolescents. It highlights the importance of producing more robust evidence and clearer guidelines for effective adolescent mental health and suicide prevention programs. Cite this article as: Sukardi NH, Mulud ZA, Razali S, Mohamad N, Ahmad N, Fitryasari R. Adolescents’ depression, anxiety, stress, suicidal ideation, and suicide prevention: a systematic review. Arch Health Sci Res. 2026, 13, 0328, doi: 10.5152/ArcHealthSciRes.2026.25328.