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This study aims to evaluate and compare the efficacy, acceptability, tolerability and safety of various pharmacological strategies for the maintenance treatment of bipolar disorder. We will conduct a systematic review and pairwise meta-analysis of randomized controlled trials (RCTs) to synthesize direct clinical evidence across major treatment modalities, including monotherapies, combination therapies, and strategies involving mood stabilizers, antipsychotics, or antidepressants.
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Taro Kishi (2026) studied this question.
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