Key result
Higher dietary inflammation score linked to ~8% higher odds of hyperlipidemia per unit.
Why the study?
Dietary inflammation is linked to dyslipidemia, but the relationship between the newer Food Inflammation Scores of Individuals (FISI) and hyperlipidemia had not been well characterized.
Are higher Food Inflammation Scores of Individuals (FISI) associated with increased odds of hyperlipidemia in U.S. adults?
Cross-Sectional (n=11,805)
Yes
Are higher Food Inflammation Scores of Individuals (FISI) associated with increased odds of hyperlipidemia in U.S. adults?
In U.S. adults, 26-item Food Inflammation Scores of Individuals (FISI26-USDA and FISI26-CHINA) were positively and linearly associated with hyperlipidemia, outperforming the 34-item FISI and the traditional Dietary Inflammatory Index after multivariable adjustment.
Answers are grounded in this paper and cite their sources.
Cross-sectional data should not yet change dietary counseling for hyperlipidemia; leaves open whether FISI scores predict incident dyslipidemia or improve cardiovascular risk stratification.
Background: Dietary inflammation has been associated with dyslipidemia, but the relationship between the newer Food Inflammation Scores of Individuals (FISI) and hyperlipidemia has not been well characterized. Methods: We analyzed 11,805 adults aged 20 years or older from five NHANES cycles (2009-2018). FISI34, FISI26-USDA, FISI26-CHINA, and a Dietary Inflammatory Index calculated without alcohol (DII) were derived from 24-h dietary recall data. Associations with hyperlipidemia were examined using survey-weighted logistic regression. Restricted cubic spline models, sex-stratified analyses, and prespecified subgroup analyses were performed. Results: In the fully adjusted model, higher FISI26-USDA and FISI26-CHINA scores were associated with greater odds of hyperlipidemia (OR 1.08, 95% CI 1.01-1.14, P=0.016; and OR 1.10, 95% CI 1.02-1.18, P=0.015, respectively). Compared with Q1, Q4 ORs were 1.35 (95% CI 1.11-1.64; P=0.003) for FISI26-USDA and 1.26 (95% CI 1.03-1.54; P=0.024) for FISI26-CHINA. FISI34 was not consistently associated with hyperlipidemia (continuous P=0.210; P for trend=0.075). The continuous DII association was weaker (P=0.072), although Q3 and the trend test remained significant. Restricted cubic splines supported approximately linear associations for FISI26-USDA, FISI26-CHINA, and DII (P for nonlinearity>0.05), whereas no overall association was detected for FISI34. In sex-stratified analyses, the FISI26 associations were more consistent among women. No significant interaction was observed across the FISI26-USDA subgroup analyses (all P for interaction>0.05). Conclusions: FISI26-USDA and FISI26-CHINA were positively associated with hyperlipidemia in U.S. adults, whereas FISI34 showed no consistent association, and the DII association was less robust after multivariable adjustment. These findings support further prospective evaluation of FISI26-based measures in cardiometabolic research.
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Wang et al. (2026) conducted a cross-sectional in Hyperlipidemia (n=11,805). Food Inflammation Scores of Individuals (FISI26-USDA, per 1-unit increase) vs. Lower FISI26-USDA score (or Quartile 1) was evaluated on Hyperlipidemia (triglycerides >=150 mg/dL, total cholesterol >=200 mg/dL, LDL-C >=130 mg/dL, HDL-C <=50 mg/dL in women or <=40 mg/dL in men, or use of lipid-lowering medication) (OR 1.08, 95% CI 1.01-1.14, p=0.016). Higher FISI26-USDA dietary inflammation scores were independently associated with increased odds of hyperlipidemia (OR 1.08 per unit, 95% CI 1.01-1.14, P=0.016; Q4 vs Q1 OR 1.35, P=0.003).
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