Key result
Omadacycline clears rare post-cannulation Mycoplasma hominis bacteremia, enabling successful LVAD implantation and recovery.
Why the study?
Hematogenous dissemination of Mycoplasma hominis is uncommon, and cases secondary to indwelling central venous catheters for extracorporeal life support are exceedingly rare.
Case Report (n=1)
No
This case report highlights that uncommon atypical urogenital pathogens like Mycoplasma hominis should be considered in the differential diagnosis and management of catheter-related bloodstream infections and associated thrombotic events following transfemoral cannulation for extracorporeal life support.
Answers are grounded in this paper and cite their sources.
May guide omadacycline selection in rare catheter-related Mycoplasma hominis bacteremia; leaves open need for prospective data before broader adoption.
Background Mycoplasma hominis(M. hominis) is a common commensal of the urogenital tract frequently associated with localized infections; however, hematogenous dissemination is uncommon, and cases secondary to indwelling central venous catheters are exceedingly rare. Here, we report a case of M. hominis bloodstream infection following transfemoral cannulation for extracorporeal life support, including an intra-aortic balloon pump (IABP) and continuous renal replacement therapy (CRRT). Case Presentation: A 68-year-old male patient underwent coronary stent implantation for acute myocardial infarction at Haining People's Hospital on July 25, 2025. Postoperatively, he developed heart failure and cardiogenic shock, necessitating IABP support. Although, his cardiac function and hemodynamics improved, and the patient’s IABP was weaned on Day 8. However, the patient subsequently developed recurrent dyspnea, along with increasing body temperature and C-reactive protein (CRP) levels. CRRT was therefore initiated to maintain fluid balance and metabolic homeostasis and to remove inflammatory mediators. Despite this, the patient continued to experience fever with persistently elevated inflammatory markers. On Day 13, blood cultures, urine cultures, and catheter tip cultures were obtained. Hemodynamic deterioration occurred on Day 15, prompting veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support. Dynamic monitoring revealed a rising trend in troponin I levels, and repeated coronary angiography demonstrated occlusion of the coronary stent, which was managed with balloon dilatation. The patient was then transferred to the First Affiliated Hospital of Zhejiang University for further management. On Day 16, the microbiology laboratory at Haining People's Hospital reported that the blood cultures yielded M. hominis ; this finding was communicated to the receiving hospital. Subsequent anti-infective therapy with omadacycline was administered. After undergoing left ventricular assist device (LVAD) implantation, the patient ultimately improved and was discharged in stable condition. Conclusions In terms of femoral catheter-related infections adjacent to the urogenital tract, uncommon atypical pathogens such as M. hominis warrant consideration in addition to routine bacterial etiologies.
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Yin et al. (2026) conducted a case report in Mycoplasma hominis catheter-related bloodstream infection following acute myocardial infarction and cardiogenic shock (n=1). Intravenous omadacycline was evaluated on Control of Mycoplasma hominis bloodstream infection and clinical recovery. Intravenous omadacycline for 26 days controlled a rare Mycoplasma hominis bloodstream infection after transfemoral cannulation, enabling LVAD implantation and discharge on Day 78.
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