Key result
Higher C-reactive protein-triglyceride glucose index linked to ~31% higher risk of repeat revascularization and restenosis.
Why the study?
The C-reactive protein-triglyceride glucose index (CTI) has been associated with cardiovascular risk, and its prognostic value for repeat revascularization and in-stent restenosis in patients with CCS undergoing PCI needed evaluation.
Does the C-reactive protein-triglyceride glucose index (CTI) predict the composite of repeat revascularization and in-stent restenosis in patients with chronic coronary syndrome undergoing percutaneous coronary intervention?
Cohort (n=2,147)
Does the C-reactive protein-triglyceride glucose index (CTI) predict the composite of repeat revascularization and in-stent restenosis in patients with chronic coronary syndrome undergoing percutaneous coronary intervention?
Answers are grounded in this paper and cite their sources.
The C-reactive protein-triglyceride glucose index is independently associated with a higher risk of repeat revascularization and in-stent restenosis after PCI in chronic coronary syndrome patients, though it adds limited incremental predictive value over conventional risk factors.
Objective The C‐reactive protein‐triglyceride glucose index (CTI) has been associated with cardiovascular risk. This study evaluated its prognostic value for repeat revascularization and in‐stent restenosis (ISR) in patients with chronic coronary syndrome (CCS) undergoing percutaneous coronary intervention (PCI). Methods A total of 2147 CCS patients undergoing PCI were stratified into CTI tertiles. The primary endpoint was a composite of repeat revascularization and ISR. Kaplan–Meier analysis with log‐rank tests was used to compare event rates. Multivariable Cox proportional hazards models and restricted cubic spline analyses were applied to assess associations. Predictive performance was evaluated using time‐dependent receiver operating characteristic curves. Results During a median follow‐up of 60 months, 992 patients (46.2%) experienced the primary endpoint. Event rates increased progressively across CTI tertiles. After multivariable adjustment, CTI remained independently associated with the primary endpoint (HR 1.11; 95% CI 1.01–1.22; p = 0.028). Compared with the lowest tertile, the highest CTI tertile was associated with a 31% higher risk (HR 1.31; 95% CI 1.10−1.55; p = 0.002). A linear dose–response relationship was observed ( p for non‐linearity = 0.172; p overall = 0.040). The multivariable model incorporating CTI showed modest discrimination, with AUCs of 0.627 (95% CI 0.602–0.651) at 3 years and 0.651 (95% CI 0.627–0.674) at 5 years. Conclusions CTI is independently associated with increased risks of repeat revascularization and ISR after PCI in patients with CCS. However, its incremental predictive value beyond conventional risk factors appears limited and requires further validation.
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Jiale et al. (2026) conducted a cohort in Chronic coronary syndrome undergoing percutaneous coronary intervention (n=2,147). C-reactive protein-triglyceride glucose index (CTI) (highest tertile / continuous) vs. Lowest CTI tertile was evaluated on Composite of repeat revascularization and in-stent restenosis (ISR) (HR 1.31, 95% CI 1.10-1.55, p=0.002). Higher C-reactive protein-triglyceride glucose index (highest vs lowest tertile) increased repeat revascularization and in-stent restenosis after PCI (HR 1.31; 95% CI 1.10-1.55; p=0.002).
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