Key result
Lipid apheresis safely lowers LDL-C without complications in post-MI familial hypercholesterolemia during pregnancy.
Why the study?
Traditional lipid-lowering pharmacotherapies are contraindicated in pregnancy, and data supporting the use of lipid apheresis during pregnancy in patients with familial hypercholesterolemia are lacking.
Case Report (n=1)
This case report supports the use of lipid apheresis as a safe and effective LDL-C lowering option during pregnancy for high-risk patients with familial hypercholesterolemia and recent myocardial infarction.
Answers are grounded in this paper and cite their sources.
May support lipid apheresis in select high-risk pregnant FH patients post-MI; leaves open confirmation in prospective studies.
Familial hypercholesterolemia (FH) is an autosomal dominant disorder characterized by severely elevated low density lipoprotein cholesterol (LDL-C) leading to premature atherosclerotic cardiovascular disease. Reducing LDL-C in FH patients is critical to prevent acute coronary syndrome (ACS) events. However, traditional lipid lowering pharmacotherapies therapies have historically been contraindicated in pregnancy. While lipid apheresis has been explored as a safe and efficacious treatment for patients with FH, there is a lack of data and literature supporting its use during pregnancy. Here, we report a case of a 40 year old pregnant patient with FH and recent myocardial infarction (MI) that was treated with lipid apheresis during pregnancy. Apheresis provided substantial LDL-C reduction and ultimately a safe pregnancy without further atherosclerotic complications. Given the limited lipid lowering options for pregnant patients, this case adds to the support of lipid apheresis during pregnancy in high-risk patients.
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Raje et al. (2026) conducted a case report in Familial hypercholesterolemia in pregnancy with recent myocardial infarction (n=1). Lipid apheresis was evaluated on LDL-C reduction and pregnancy safety without further atherosclerotic complications. Lipid apheresis in a 40-year-old pregnant woman with familial hypercholesterolemia and recent MI provided substantial LDL-C reduction and a safe pregnancy without further complications.
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