LANaPDB: A web-based platform for the Latin American Natural Product Database

Natural products (NPs) have a major impact on several research areas, including drug discovery and development, food and agricultural chemistry, and the cosmetic industry. Annotated compound databases of NPs provide a structured and organized framework that facilitates access to information, particularly if the compound database is freely available. Over the past few years, a compound library from eight countries, called the Latin American Natural Product Database (LANaPDB), has been assembled, curated, and annotated and currently contains 14,741 unique compounds. The compounds are annotated with extensive bioactivity data retrieved from the peer-reviewed literature, along with structural information (e.g., chirality, taxonomic and structural classification), accessibility (commercial availability or estimated synthetic feasibility), and other properties of interest in drug discovery. Although all the information in LANaPDB is in the public domain and documented in the peer-reviewed literature, it was not available through a free website that enabled rapid and intuitive access to all the information. The goal of this manuscript is to introduce and describe a freely available web server dedicated to systematically and intuitively exploring the contents of LANaPDB. The website provides a dynamic interface that spans from basic to advanced structural and information search, multi-parameter filtering, interactive visualization of phylogenetic and chemotaxonomic diversity, geographical mapping of compound origins, and molecular structure rendering. It is also possible to download the entire compound database from the website. The website facilitates the exploration of Latin American NPs and multidisciplinary research. The web-based platform of LANaPDB is https://www.lanapdb.com/.