Key result
Infective endocarditis in adults with congenital heart disease carries ~4% in-hospital mortality.
Observational (n=822)
Yes
In a nationwide Japanese cohort of adults with congenital heart disease hospitalized for infective endocarditis, in-hospital mortality was 4.0% and was independently associated with older age, severe CHD complexity, and pulmonary hypertension.
Answers are grounded in this paper and cite their sources.
May inform risk stratification in adult CHD-IE; extends observational data but requires prospective validation before guiding care.
Background: Nationwide data on infective endocarditis (IE) in adults with congenital heart disease (ACHD) in Japan are limited. Methods and Results: Using a nationwide Japanese administrative database (2013–2023), we identified 822 ACHD patients (median age 41 years; 32.0% female) hospitalized for IE. In-hospital mortality rate was 4.0%, and cardiac surgery was performed in 38.6%. Older age, severe CHD complexity, and pulmonary hypertension were independently associated with in-hospital death. Conclusions: This study clarified the clinical characteristics and outcomes of IE in ACHD in Japan.
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Machino‐Ohtsuka et al. (2026) conducted an observational in Infective endocarditis in adults with congenital heart disease (n=822). Infective endocarditis in adults with congenital heart disease was evaluated on In-hospital mortality. Adults with congenital heart disease hospitalized for infective endocarditis in Japan had a 4.0% in-hospital mortality rate and a 38.6% cardiac surgery rate.
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