Key result
Combination therapy and integrated care target post-stroke systolic BP below 130 mm Hg.
Why the study?
Although high blood pressure is the main modifiable risk factor for preventing cardiovascular events after stroke or transient ischaemic attack, only approximately one in three people who have had a stroke have adequate blood pressure control, highlighting the need to change conventional models of care.
Does broader adoption of combination antihypertensive therapy, integrated multidisciplinary care, and novel preventative strategies improve blood pressure control (<130 mm Hg systolic) and reduce cardiovascular events in people who have had a stroke or transient ischaemic attack?
Does broader adoption of combination antihypertensive therapy, integrated multidisciplinary care, and novel preventative strategies improve blood pressure control (<130 mm Hg systolic) and reduce cardiovascular events in people who have had a stroke or transient ischaemic attack?
Because only about one in three stroke survivors achieve adequate blood pressure control, shifting from conventional care to single-pill combination antihypertensive regimens targeting systolic blood pressure <130 mm Hg, multidisciplinary care, and digital/dietary innovations is essential for secondary stroke prevention.
Answers are grounded in this paper and cite their sources.
May guide post-stroke SBP targets with combination regimens; leaves open randomized confirmation of event reduction.
High blood pressure is the main modifiable risk factor for preventing cardiovascular events in people who have had a stroke or transient ischaemic attack; however, only approximately one in three people who have had a stroke have adequate blood pressure control, which highlights the need for a change to conventional models of care. New priorities include the broader adoption of combination antihypertensive therapy to maintain systolic blood pressure below 130 mm Hg, with an emphasis on simplified regimens and single pill combinations. Integrated multidisciplinary models of care, coupled with scalable community-based strategies, are essential to overcome therapeutic inertia and fragmentation. Digital health technologies, remote monitoring, potassium-enriched low-sodium salt substitutes, and novel pharmacological agents offer other opportunities to improve preventative care. Effective blood pressure control is a collective imperative to reduce the global burden of stroke and improve long-term outcomes in people with cerebrovascular disease.
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Gnanenthiran et al. (2026) conducted a review in History of stroke or transient ischaemic attack with high blood pressure. Combination antihypertensive therapy (including single pill combinations), integrated multidisciplinary care models, digital health technologies, remote monitoring, potassium-enriched low-sodium salt substitutes, and novel pharmacological agents vs. Conventional models of care was evaluated on Blood pressure control (maintaining systolic blood pressure below 130 mm Hg) and prevention of cardiovascular events and recurrent stroke. Combination antihypertensive therapy and integrated care aim to maintain systolic blood pressure <130 mm Hg post-stroke, addressing the ~1 in 3 rate of adequate control.
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