Role of Sirtuins in the Hallmarks of Skin Aging

Sirtuins are a family of enzymes that regulate cell homeostasis through pathways impacting genomic stability, mitochondrial function, cellular senescence, inflammation, and autophagy. In the skin, these pathways protect against extrinsic insults, maintain keratinocyte stem cells, and contribute to the overall structure and integrity of the skin barrier. Sirtuins decline with chronologic age, with UV exposure also impacting their activity, resulting in a loss of this homeostasis. There are 13 established biological hallmarks of aging. This review presents the current evidence of the mechanistic roles of sirtuins for each of these hallmarks, particularly in relation to skin.