Key result
Scoping review protocol maps CVD risk prediction models for people with HIV in Sub-Saharan Africa.
Why the study?
Cardiovascular disease is a leading cause of morbidity and mortality in people living with HIV, making risk assessment imperative. However, data on CVD risk prediction models developed or applied among people living with HIV in sub-Saharan Africa are scanty.
Systematic Review
This scoping review protocol outlines a systematic approach to map and evaluate existing cardiovascular disease risk prediction models for people living with HIV in Sub-Saharan Africa to identify gaps and inform context-specific model development.
Answers are grounded in this paper and cite their sources.
External CVD risk models should not yet guide care for HIV patients in SSA; protocol maps gaps to inform local tool development.
Background The landscape of Human Immunodeficiency Virus (HIV) care has dramatically shifted with the advent of effective antiretroviral therapy (ART), transforming HIV from a rapidly fatal illness into a chronic, manageable disease. This success, however, has unveiled new challenges, primarily the increased prevalence of non-AIDS-related comorbidities, with non-communicable diseases (NCDs) such as cardiovascular disease (CVD) emerging as a critical concern for people living with HIV (PLWH). CVD has now become a leading cause of morbidity and mortality in this population, and its risk assessment is imperative. However, there is scanty data on CVD risk prediction models developed and/or applied among PLWH in sub-Saharan Africa (SSA). Therefore, this planned scoping review aims to systematically map existing literature on CVD risk prediction models developed and/or used among PLWH in SSA. The review will identify the models that have been developed, used, and validated in the region. Methods The scoping review protocol will follow an established framework for conducting scoping reviews. The study will employ the methodological approaches by Arksey and O’Malley and its recent advances, the Joanna Briggs Institute, and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols. The objective of the scoping review will be achieved through a comprehensive published literature search from 01 January 2000 to 03 June 2026 across five selected databases: PubMed, Scopus, Web of Science, Google Scholar, and CINAHL, based on a predefined strategy. Inclusion criteria will focus on studies written in English that develop, validate, or apply CVD risk prediction models among PLWH in SSA. The screening of search results and data extraction will be conducted by two independent reviewers. Expected outcomes and conclusions The review will synthesize and summarize the existing literature on CVD risk prediction developed and used among PLWH in SSA, identify knowledge gaps, and provide insights to inform the development of a novel CVD risk prediction model specific to PLWH in SSA. Registration: Open Science Framework https://doi.org/10.17605/OSF.IO/XVFUA
No takes yet. Share an insight, caveat, or question.
Ntiyani et al. (2026) conducted a systematic review in Human Immunodeficiency Virus (HIV) and cardiovascular disease risk. Cardiovascular disease risk prediction models was evaluated on Model characteristics, included predictors, and model performance (discrimination and calibration) in predicting cardiovascular disease outcomes (myocardial infarction, coronary heart disease, angina, stroke, peripheral arterial disease, heart failure, cardiovascular death, or composite cardiovascular events). Cardiovascular disease risk prediction models for people living with HIV in Sub-Saharan Africa are being systematically mapped in this scoping review protocol, with no results generated yet.
Synapse has enriched 10 related papers. Consider them for comparative context: