Pathways to progress: navigating the evolving field of PIDs and associated conditions — proceedings from the IPOPI Global Multi-Stakeholders’ Summit (July 2025)

Introduction In July 2025, the International Patient Organisation for Primary Immunodeficiencies (IPOPI) held its fourth consecutive Global Multi-Stakeholders’ Summit, bringing together key stakeholders and experts in primary immunodeficiencies (PIDs) and related fields to discuss current challenges and opportunities for improving patient care. Methods This edition focused on current and projected trends to 2035 in artificial intelligence and quantum computing, the gap between primary and secondary immunodeficiencies, and the role of preventive medicine in patients’ quality of life. Results Stakeholders from all around the world gathered to examine current knowledge gaps, needs and avenues to improve the care of patients with immunodeficiency in the next ten years. Discussion Recommendations on how digital technologies can contribute to equitable access to innovative therapies are proposed. Mechanisms by which multidisciplinary teams can work together to improve the care of patients with immunodeficiencies are outlined, including how innovative screening and care plans can reduce the risk of multiorgan involvement and complications in these patients. Within the next decade, digital tools in conjunction with improved multistakeholder collaborations is most likely to contribute to the collection of standardised data, inclusive studies, and personalised treatments that will prolong, with quality, the lives of patients with immunodeficiencies.