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Summary A mismatch repair‐deficient glioblastoma acquired a second SMARCB1 mutation with complete loss of SMARCB1 protein expression at recurrence. Acquired SMARCB1 deficiency may represent a progression‐associated event in mismatch repair‐deficient glioblastoma and also constitute a diagnostic pitfall.
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Kuellenberg et al. (2026) studied this question.
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