The relationship between sirtuin1 gene polymorphism and coronary heart disease: Systematic review and meta-analysis

Background: This study systematically assesses the relationship between sirtuin (SIRT)1 gene polymorphisms rs4746720T > C, rs3818292G > A, rs7895833 A > G, and rs7069102C > G with the risk of coronary heart disease (CHD). Methods: PubMed, Embase, Web of Science, and Cochrane databases were searched for literature examining the connection between SIRT1 gene polymorphism and CHD. The search time limit was from the establishment of the database to June 15, 2024. Stata 15.0 software was used for data analysis. Results: A total of 9 articles were included (1839 cases in the case group and 1937 cases in the control group). Meta-analysis showed that the rs4746720 dominant model (TC + TT > CC) [odds ratio = 1.321, 95% confidence interval (1.032–1.692), P = .027] was nominally associated with an increased risk of CHD, although this association did not remain significant after correction for multiple testing (Benjamini–Hochberg adjusted q = 0.176), whereas the rs7069102 dominant model (CC + CG > GG) [odds ratio = 0.278, 95% confidence interval (0.126–0.612), P = .001] was associated with a decreased risk of CHD and remained significant after correction (adjusted q = 0.013). However, the rs7069102C > G, rs7069102CC > GG, rs7069102 CG > GG, rs7069102CC > CG + GG, rs4746720T > C, rs4746720TC > TT, rs7895833 and rs3818292 gene polymorphisms were not associated with the risk of CHD. Conclusion: The rs7069102 CC + CG genotype of SIRT1 may be associated with a reduced risk of CHD, whereas the association between the rs4746720 TC + TT genotype and CHD risk was only nominally significant and did not withstand correction for multiple comparisons. However, limited by the quantity and quality of the included studies, the above conclusions need to be verified by more high-quality studies.