Key result
Increased ApoB in small dense LDL particles predicts premature CAD, while lowering LDL cholesterol with statin therapy reduces CAD events by up to 50%.
Answers are grounded in this paper and cite their sources.
Demonstrates that elevated ApoB in small dense LDL particles predicts premature coronary artery disease, highlighting evolving lipoprotein risk assessment.
he relation between plasma lipoproteins and atherosclerosis has evolved over the past fifty years.Serum cholesterol levels were shown to be associated with coronary artery disease (CAD) in familial hypercholesterolemia in the early 20 th century (see Frederickson 1 ).This cholesterol was determined to be in a particular lipoprotein class 2 now termed low-density lipoprotein (LDL) cholesterol.3 LDL cholesterol has been shown to predict premature CAD in many studies, 4 and a reduction in LDL cholesterol with statin therapy has been shown to decrease CAD events by up to 50% in primary 5 and in secondary 6 intervention trials.The National Cholesterol Education Program Adult Treatment Panel 7 initially based recommendations for therapy to prevent CAD on LDL cholesterol levels.Later the measurement of HDL cholesterol was added to estimate risk.
No takes yet. Share an insight, caveat, or question.
John D. Brunzell (2005) conducted an editorial in Premature coronary artery disease (CAD) and atherosclerosis. ApoB in small dense LDL particles / LDL cholesterol was evaluated on Premature coronary artery disease (CAD) events. Increased ApoB in small dense LDL particles predicts premature CAD, while lowering LDL cholesterol with statin therapy reduces CAD events by up to 50%.
Synapse has enriched 10 related papers. Consider them for comparative context: