Study on the Mechanism of Changmaile Capsules in Regulating P4HA1-Mediated Atherosclerotic Plaque Stability

Q: What is the clinical evidence from this study?

Study design: Review. Population: Atherosclerosis. Intervention: Changmaile Capsules. Primary outcome: Atherosclerotic plaque stability via P4HA1-mediated collagen synthesis.

Q: What does this research mean for the field?

Changmaile Capsules enhance atherosclerotic plaque stability by promoting collagen synthesis through multi-pathway regulation of P4HA1 via Akt/Sp1 and AMPKα/AP-2α signaling networks. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

宽 张

doi:10.12677/md.2026.165073

January 1, 2026Medical DiagnosisOpen Access

Study on the Mechanism of Changmaile Capsules in Regulating P4HA1-Mediated Atherosclerotic Plaque Stability

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Key result

Changmaile Capsules may promote atherosclerotic plaque stability by boosting P4HA1-mediated collagen synthesis.

Why the study?

Changmaile Capsules improve vascular endothelial function and combat atherosclerosis, while P4HA1 regulates vascular wall fibrosis and plaque stability, motivating an exploration of the scientific basis for how Changmaile Capsules regulate P4HA1 in atherosclerosis.

Key Points

To review the pathological mechanisms connecting extracellular matrix remodeling and P4HA1 in atherosclerosis and evaluate how Changmaile Capsules regulate P4HA1 to enhance plaque stability.
Synthesized molecular and pharmacological evidence examining collagen metabolism, fibrous cap integrity, and prolyl 4-hydroxylase subunit alpha-1 (P4HA1) in atherosclerosis.
Summarized mechanistic and network pharmacology findings on Changmaile Capsules across multiple pathways, including PPAR, Wnt, AMPK, and Akt signaling networks.
P4HA1 functions as the rate-limiting enzyme in collagen synthesis; in ApoE−/− mouse models, lentivirus-mediated P4HA1 overexpression increased collagen and smooth muscle cell content while suppressing MMP-2 and MMP-9 activity to stabilize plaques.
Changmaile Capsules contain multiple bioactive constituents that potentially converge on P4HA1 through Akt/Sp1 and AMPKα/AP-2α signaling axes to promote collagen synthesis and preserve extracellular matrix balance.

Structured PICO

P

Population

Atherosclerosis (preclinical models and clinical contexts discussed in review)

I

Intervention

Changmaile Capsules (a Traditional Chinese Medicine formulation containing Astragalus membranaceus, Salvia miltiorrhiza, Polygonum multiflorum, Curcuma aromatica, Pueraria lobata, Paeonia rubra, Gastrodia elata, etc.)

O

Outcome

Atherosclerotic plaque stability and collagen synthesis mediated by Prolyl 4-Hydroxylase Subunit Alpha-1 (P4HA1)surrogate

This review outlines the theoretical molecular mechanism by which Changmaile Capsules may stabilize vulnerable atherosclerotic plaques by regulating P4HA1-mediated collagen synthesis via the Akt/Sp1 and AMPKα/AP-2α signaling pathways.

Limitations

Narrative mechanism review without new primary experimental or clinical trial data
Direct experimental verification in ApoE-/- mouse models is still needed to confirm the effect of Changmaile Capsules on plaque P4HA1 expression and collagen content
Lack of P4HA1 gene knockout or specific inhibitor intervention studies to confirm the necessity of P4HA1 in the collagen-promoting effects of Changmaile Capsules
Specific active ingredients targeting P4HA1 and their structure-activity relationships remain to be elucidated
Previous studies on Changmaile Capsules paid less attention to its role in extracellular matrix synthesis, particularly collagen metabolism.
Further molecular biology experiments and preclinical studies in animal models (e.g., ApoE-/- mice) are needed to clarify the exact site of action and directly verify the effect on P4HA1 expression and collagen content.

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Implication

Hypothesis-generating for Changmaile Capsules in plaque stabilization; leaves open clinical validation of P4HA1 modulation.

Abstract

Atherosclerosis serves as the core pathological basis for cardiovascular and cerebrovascular diseases.Its onset and progression are closely associated with vascular endothelial injury, abnormal lipid metabolism, macrophage foam cell formation, and extracellular matrix remodeling.Prolyl 4hydroxylase subunit alpha-1 (P4HA1) is a key enzyme in collagen synthesis and the hypoxic response, playing a crucial role in regulating vascular wall fibrosis, plaque stability, and inflammation within the local microenvironment.Changmaile Capsules have demonstrated definite efficacy in improving vascular endothelial function and combating atherosclerosis.This paper systematically reviews the pathological regulatory mechanisms linking extracellular matrix remodeling and P4HA1 in atherosclerosis.It explores in depth the potential scientific basis underlying the multi-target and multipathway regulation of P4HA1 by Changmaile Capsules in exerting anti-atherosclerotic effects, aiming to provide a theoretical foundation for targeting P4HA1 with Changmaile Capsules to intervene in atherosclerosis.

Discussion

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Cite This Study

宽张 (2026) conducted a review in Atherosclerosis. Changmaile Capsules was evaluated on Atherosclerotic plaque stability via P4HA1-mediated collagen synthesis. Changmaile Capsules may enhance atherosclerotic plaque stability by promoting collagen synthesis through multi-pathway regulation of P4HA1 via Akt/Sp1 and AMPKα/AP-2α signaling networks.

synapsesocial.com/papers/6af0cd87afd0f3f56e51a218 https://doi.org/10.12677/md.2026.165073

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Study on the Mechanism of Changmaile Capsules in Regulating P4HA1-Mediated Atherosclerotic Plaque Stability

Key Points

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Study on the Mechanism of Changmaile Capsules in Regulating P4HA1-Mediated Atherosclerotic Plaque Stability

Key Points

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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