Key result
Elevated serum uric acid is linked to acute MI and unfavorable lipid profiles.
Why the study?
Although hyperuricemia is connected to metabolic syndrome, coronary artery disease, and stroke, data on the relationship of serum uric acid with dyslipidemia in patients with acute myocardial infarction were limited.
Cross-Sectional (n=204)
No
Elevated serum uric acid levels are significantly associated with an atherogenic lipid profile—higher LDL-C, triglycerides, and total cholesterol, and lower HDL-C—in patients presenting with a first acute myocardial infarction.
Answers are grounded in this paper and cite their sources.
Uric acid-lipid correlations in acute MI are hypothesis-generating; leaves open causal role and need for prospective outcome trials.
Background: Myocardial infarction is a common presentation of coronary artery disease or ischemic heart disease. The connection between hyperuricemia and various diseases like metabolic syndrome, coronary artery disease and stroke had been recognized still data on the relationship of serum uric acid (SUA) with dyslipidemia in patients with acute myocardial infarction (AMI) are limited. This study was carried out to evaluate the association of serum uric acid with lipid profile in patients with first episodes of acute myocardial infarction (AMI) at ARMCH & RC, Kumbhari, Solapur. Materials & Methods: This was a hospital based cross-sectional analytical study involving 104 AMI patients admitted in intensive care unit and 100 were healthy controls in ARMCH & RC, Kumbhari, Solapur between Dec 2023 to Nov 2025. Important determinants in this study were serum uric acid, serum LDL-C, HDL-C, total cholesterol, triglycerides, Body mass index, waist circumference, age and gender. Pearson’s correlation coefficient test was used to analyse the association between SUA and lipid levels. Results: Out of 104 patients with AMI, 64 (61.5%) were males and 40 (38.5%) were females. The mean age of the participants was 54.76 ± 12.81 years, with an age ranging from 30–80 years. The mean SUA levels were significantly higher in males (7.68 ± 1.42 mg/dl) compared with females (6.37 ± 1.26 mg/dl) (p < 0.01). Significantly elevated SUA levels and lipid parameters were observed in AMI patients compared to healthy controls (P<0.01). Pearson’s correlation demonstrated a significant positive correlation between SUA and TG and LDL-C levels (p < 0.01), while a weaker but statistically significant positive association was observed with TC levels (p = 0.01). In contrast, SUA levels showed a significant inverse relationship with HDL-C levels (p < 0.01). Furthermore, a significant association (p < 0.001) was found between SUA and individual lipid components in the regression models. Conclusion: The present study demonstrated Dyslipidemia and its components were more prevalent in individuals with hyperuricemia than in those without. This strengthens the association between hyperuricemia and an atherogenic lipid profile in AMI patients. Early identification and management of hyperuricemia and dyslipidemia may contribute to reducing the burden of cardiovascular diseases associated with AMI
No takes yet. Share an insight, caveat, or question.
A 2026 study conducted a cross-sectional in Acute myocardial infarction (n=204). Serum uric acid / Hyperuricemia vs. Healthy controls / Normal serum uric acid was evaluated on Serum uric acid levels (mg/dL) in acute myocardial infarction cases vs healthy controls (p=<0.01). Serum uric acid was higher in acute MI patients vs controls (7.28 vs 4.69 mg/dL, p<0.01) and correlated with TG (r=0.409), LDL-C (r=0.326), and HDL-C (r=-0.510; all p<0.01).
Synapse has enriched 10 related papers. Consider them for comparative context: