Key result
Inotropes and IVIG fail to prevent fatal progression of parainfluenza type 3 fulminant myocarditis.
Why the study?
Parainfluenza virus type 3 is an uncommon cause of myocarditis.
Case Report (n=1)
Highlights that parainfluenza virus type 3 can cause fatal fulminant myocarditis and rapidly progressive dilated cardiomyopathy in adolescents, underscoring the critical need for early recognition and timely access to mechanical circulatory support.
Answers are grounded in this paper and cite their sources.
Rapid progression to death despite inotropes and IVIG in this adolescent case; leaves open whether early mechanical support improves survival.
Parainfluenza virus type 3 is an uncommon cause of myocarditis. [1] A previously healthy 13-year-old girl presented with a 1-week history of fever and cough followed by rapid cardiogenic shock with markedly elevated cardiac biomarkers and severe left ventricular dysfunction (ejection fraction <10%). Respiratory RT-PCR detected parainfluenza virus type 3 as the sole pathogen. Despite aggressive inotropic support, milrinone, levosimendan, and intravenous immunoglobulin, ventricular function did not recover, and she progressed to end-stage dilated cardiomyopathy and died within 1 month. Early recognition and timely access to mechanical circulatory support are critical.
No takes yet. Share an insight, caveat, or question.
Deodhar et al. (2026) conducted a case report in Parainfluenza virus type 3-related fulminant myocarditis and cardiogenic shock (n=1). Aggressive inotropic support, milrinone, levosimendan, and intravenous immunoglobulin was evaluated on Ventricular function recovery, progression to end-stage dilated cardiomyopathy, and death within 1 month. Parainfluenza virus type 3-related fulminant myocarditis (LVEF <10%) progressed to end-stage dilated cardiomyopathy and death within 1 month despite milrinone, levosimendan, and IVIG.
Synapse has enriched 10 related papers. Consider them for comparative context: