Key result
Male sex is linked to ~2.5-fold higher cardiac organ damage in hypertensive emergencies.
Why the study?
Hypertensive emergency involves severe blood pressure elevation with acute target end-organ damage, motivating an evaluation of how organ damage correlates with age and gender among patients presenting to a tertiary care centre.
Does age or gender correlate with the pattern of acute target end-organ damage in patients presenting with hypertensive emergency?
Observational (n=67)
No
Does age or gender correlate with the pattern of acute target end-organ damage in patients presenting with hypertensive emergency?
In this Indian tertiary care cohort, hypertensive emergencies predominantly occurred in known hypertensives with poor medication adherence, resulting primarily in neurological and cardiac end-organ damage, with males experiencing significantly higher rates of cardiac involvement.
Answers are grounded in this paper and cite their sources.
Suggests male sex may associate with greater cardiac damage in hypertensive emergency; leaves open need for prospective validation before clinical adoption.
Background: Hypertensive emergency is a serious clinical condition characterized by severe elevation of blood pressure with acute target end-organ damage, requiring urgent evaluation and management. Aim: To assess the correlation between hypertensive emergencies and target end-organ damage among different age groups and genders in patients presenting to a tertiary care centre. Materials and Methods: This hospital-based observational study included 67 patients diagnosed with hypertensive emergency. Demographic details, hypertension history, treatment status, presenting symptoms, and evidence of target organ involvement were recorded. Neurological, cardiac, renal, and ocular damage were evaluated using clinical examination, electrocardiography, echocardiography, renal function tests, ultrasonography, and fundus examination. Associations with age and gender were statistically analyzed. Results: The mean age of patients was 54.48 ± 13.51 years, with most cases occurring in middle-aged and elderly individuals. Males constituted 59.7% of the study population. Headache was the commonest presenting symptom, followed by dyspnoea and chest pain. Neurological and cardiac involvement were the predominant forms of target organ damage, while renal and fundus changes were less frequent. Age showed significant association only with ECG ST-T changes, whereas gender showed no significant association with organ damage or outcome. Conclusion: Hypertensive emergencies were mainly associated with poor blood pressure control and predominantly involved neurological and cardiac systems.
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Pandey et al. (2026) conducted an observational in Hypertensive emergency (n=67). Male sex (and age groups in hypertensive emergency) vs. Female sex was evaluated on Target end-organ damage (specifically cardiac involvement by gender) (p=0.026). Male patients with hypertensive emergency had significantly higher cardiac target organ damage than females (27.5% vs 11.1%, p=0.026), while neurological (22.4%) and cardiac (20.9%) damage predominated overall.
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